Friday, June 8, 2012

Bad news, more good news

Bad news first - another fellow fighter has fallen.  Jake, author of the excellent blog Jake's Take - succumbed to the disease last week.  Jake and I both went through the TIL procedure around the same time and both had negative results and have been going through many of the same things over the past year.  My thoughts go out to his wife, children and family.  Jake set the bar for humor, strength and humility.

For the good news - continued success with the combination therapy.  News of this has hit the press from the ASCO conference.

Glaxo Melanoma Drugs Beat Standard Chemotherapy In Study

BLOOMBERG - By Makiko Kitamura and Robert Langreth - Jun 4, 2012 12:00 AM ET

Two experimental GlaxoSmithKline Plc (GSK) drugs that block genes tied to lethal skin cancer worked better than chemotherapy in studies that tested them individually, paving the way for final-phase trials on their use together.
About 80 percent of patients with advanced melanoma given Glaxo’s trametinib were alive after six months, compared with 67 percent on chemotherapy used as a standard treatment. Separately, Glaxo’s dabrafenib delayed disease progression by 5.1 months, compared with 2.7 months for chemotherapy. The Glaxo-funded research is being reported today at the American Society of Clinical Oncology meeting in Chicago.
The individual research followed an early-stage study in 77 patients that found the drugs used together resulted in fewer skin lesions than previously reported with Roche Holding AG (ROG)’s Zelboraf, a therapy cleared last year that targets a mutant gene found in half of advanced melanoma cases. Glaxo has begun two final-stage trials on the combo therapy, the company said.
The combination “is where we have the most enthusiasm right now,” said Keith Flaherty, director for developmental cancer therapeutics at Massachusetts General Hospital in Boston, and an author on the trametinib study. It “looks better in terms of efficacy, and better in terms of safety.”
The U.S. will have an estimated 76,250 new cases of melanoma this year, with 9,180 deaths, according to the National Cancer Institute. While patients with early-stage disease respond well to treatment, the five-year survival rate for those with cancer that has spread is 15 percent, according to the American Cancer Society.
Billion-Dollar Drugs
Approval of the two Glaxo drugs could generate as much as 1.5 billion pounds ($2.35 billion) in 2020, said Andrew Baum, a London-based analyst at Citigroup Inc., said in a note to investors last week. The company will seek regulatory approval of both compounds individually later this year.
In an interview, Paolo Paoletti, president of the oncology unit for London-based Glaxo, said his company has begun two late-stage trials of the combination therapy in advanced skin cancer. One will compare the combination to dabrafenib alone; the other compares the combo to Roche’s Zelboraf.
“We are rolling; the interest is so great the enrollment will be very quick,” said Paoletti. If the benefits of teaming the two drugs hold up, “it is a transformation. It will be a new standard of care.”
Zelboraf and Glaxo’s dabrafenib work by blocking BRAF, a mutant gene that spurs cancer cell growth in about half of melanoma patients. Zelboraf was approved in the U.S. in August 2011. Trametinib is designed to thwart a related protein called MEK that helps tumors resist an assault on BRAF.
‘Gold Standard’
With few side effects, the combination therapy could become the industry “gold standard” in treating melanoma patients with the BRAF mutation as early as 2014, CitiGroup’s Baum said.
One downside of the BRAF-blocking drugs is that using them may activate certain growth pathways in healthy cells, leading to non-melanoma skin cancers. Adding the MEK drug can block the formation of these skin lesions, it turns out, Flaherty said.
Finding out that a second drug can cancel out the side effects of the first “was the cool part,” Glaxo’s Paoletti said. “Usually, when you combine two drugs they increase toxicity.”
Glaxo’s move into combination trials was “so gutsy,” said George Demetri, an oncologist at Dana Farber Cancer-Institute in Boston. “Glaxo did a spectacular job.” Demetri said he was a scientific adviser for one of Roche’s partners in the development of Zelboraf.


  1. I am Mariam used every single spell worker on the internet, spent untold amounts of money and discovered they are all fakes...i was the fool though; doing the same thing over and over again and expecting different results. In the end, I decided that I wanted a tarot reading to know what my future held for me; I contacted a woman who lives locally to me and she told me about a man named (Priests Irumole); he does not advertise on the internet, has another job for income, has no set prices, makes no false promises and refuses to help anyone that cannot be helped and even helps
    for free sometimes, he will give you proof before taking money. He is a wonderful man and he was the only person who actually gave me real results. I really hope he doesn't mind me advertising his contact on the internet but I'm sure any help/ extra work will benefit him as He travel sometimes.i cant give out his number cos he told me he don’t want to be disturbed by many people across the world..he said his email is okay and he’ will replied to any emails asap,love marriage,finance, job promotion ,lottery Voodoo,poker voodoo,golf Voodoo,Law & Court case Spells,money voodoo,weigh loss voodoo,any sicknesses voodoo,Trouble in marriage,HIV AIDS,it's all he does Hope this helps everyone that is in a desperate situation as I once was; I know how it feels to hold onto something and never have a chance to move on because of the false promises and then to feel trapped in wanting something

  2. شركة تنظيف مجالس بالإحساء

    تساعد المجالس على الجلوس براحة أكبر سواء لمشاهدة التلفزيون مع العائلة، أو لاستضافة الأصدقاء والضيوف أو لتناول الطعام بشكل يومي أو فى المناسبات والأعياد، إلا أن اتساخها يمثل مشكلة كبيرة يصعب التخلص منها، لذلك تقوم شركة تنظيف مجالس بالإحساء بتنظيف جميع أنواع المجالس المختلفة مهما كان نوعها أو حجمها من خلال فريق عمل مميز قادر على التعامل مع أشد أنواع البقع والدهون المختلفة حتي تلك التي لا يمكن إزالتها، وتعيد المجلس جديدا كما كان.
    لذلك يلجأ الكثيرون إلى شركة تنظيف مجالس بالإحساء للمساعدة على حل مشكلة اتساخ المجالس بمدينة الإحساء حتي تظل جاهزة لاستقبال الضيوف او استخدامها بشكل يومي، والذي تنعكس نظافتها بدورها على الراحة النفسية لأهل البيت.

  3. I am 29 years old and have been diagnosed with breast cancer, ease of treatment and a similar story, except for my first acceptance as a rejection of herbal medicine. I was not part of the Perseid movement and did not really build relationships with any of them, I just believed in their operation. I say this because it was during the use of Dr. Itua herbal medicine that I now attest that herbal medicine is real, the phytotherapy Dr. Itua heal my breast cancer which I suffered for 2 years. Dr. Itua herbal medicine is made of natural herbs, with no side effects, and easy to drink. If you have the same breast cancer or any type of human illness, including HIV / AIDS, herpes cancer, bladder cancer, bladder cancer, prostate cancer, kidney cancer, lung cancer, skin cancer, skin cancer and skin cancer. , LEUKEMIA, VIRUSES, HEPATITIS, INFERTILITY WOMEN / MAN, LOT OF LOVE, LOTTERY. ITS CONTACT EMAIL / WHATSAPP: Or +2348149277967